Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice

Microcystin-leucine arginine induced the apoptosis of GnRH neurons by activating the endoplasmic reticulum stress resulting in a decrease of serum testosterone level in mice

Microcystin-leucine arginine (MC-LR) is a kind of toxin produced by cyanobacterial, resulting in decrease of testosterone levels in serum and leading to impaired spermatogenesis. Gonadotropin-releasing hormone (GnRH) neurons play crucial roles in the regulation of testosterone release. Meanwhile, it...

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Bibliographic Details
Main Authors: Haibo Jin, Jiwei Hou, Xiannan Meng, Tan Ma, Bo Wang, Zhenyu Liu, Xiaoxuan Sha, Jie Ding, Xiaodong Han
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
MC-LR
GnRH neurons
Endoplasmic reticulum stress
Autophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651320315840

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http://www.sciencedirect.com/science/article/pii/S0147651320315840

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