Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.

Environmental exposure of the mouse germ line: DNA adducts in spermatozoa and formation of de novo mutations during spermatogenesis.

BACKGROUND: Spermatozoal DNA damage is associated with poor sperm quality, disturbed embryonic development and early embryonic loss, and some genetic diseases originate from paternal de novo mutations. We previously reported poor repair of bulky DNA-lesions in rodent testicular cells. METHODOLOGY/PR...

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Bibliographic Details
Main Authors: Ann-Karin Olsen, Ashild Andreassen, Rajinder Singh, Richard Wiger, Nur Duale, Peter B Farmer, Gunnar Brunborg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2893163?pdf=render

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http://europepmc.org/articles/PMC2893163?pdf=render

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