Directed evolution of a three-finger neurotoxin by using cDNA display yields antagonists as well as agonists of interleukin-6 receptor signaling

<p>Abstract</p> <p>Background</p> <p>Directed evolution of biomolecules such as DNA, RNA and proteins containing high diversity has emerged as an effective method to obtain molecules for various purposes. In the recent past, proteins from non-immunoglobulins have attrac...

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Bibliographic Details
Main Authors: Naimuddin Mohammed, Kobayashi Suzuko, Tsutsui Chihiro, Machida Masayuki, Nemoto Naoto, Sakai Takafumi, Kubo Tai
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Molecular Brain
Online Access:http://www.molecularbrain.com/content/4/1/2