High Tidal Volume Induces Mitochondria Damage and Releases Mitochondrial DNA to Aggravate the Ventilator-Induced Lung Injury

High Tidal Volume Induces Mitochondria Damage and Releases Mitochondrial DNA to Aggravate the Ventilator-Induced Lung Injury

ObjectiveThis study aimed to determine whether high tidal volume (HTV) induce mitochondria damage and mitophagy, contributing to the release of mitochondrial DNA (mtDNA). Another aim of the present study was to investigate the role and mechanism of mtDNA in ventilator-induced lung injury (VILI) in r...

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Bibliographic Details
Main Authors: Jin-Yuan Lin, Ren Jing, Fei Lin, Wan-yun Ge, Hui-jun Dai, Linghui Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
ventilator-induced lung injury
toll-like receptor 9/myeloid differentiation factor 88/nuclear factor-κB signaling pathway
mitochondrial DNA
mitophagy
mitochondrial damage
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01477/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01477/full

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