Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understood. We show here that inhibition of lysosomal acidi...

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Bibliographic Details
Main Authors: King Faisal Yambire, Christine Rostosky, Takashi Watanabe, David Pacheu-Grau, Sylvia Torres-Odio, Angela Sanchez-Guerrero, Ola Senderovich, Esther G Meyron-Holtz, Ira Milosevic, Jens Frahm, A Phillip West, Nuno Raimundo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
iron
lysosome
acidification
inflammation
mitochondria
brain
Online Access:https://elifesciences.org/articles/51031

Internet

https://elifesciences.org/articles/51031

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