The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy

The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy

Pilocarpine-induced status epilepticus (SE), which results in temporal lobe epilepsy (TLE) in rodents, activates the JAK/STAT pathway. In the current study, we evaluate whether brief exposure to a selective inhibitor of the JAK/STAT pathway (WP1066) early after the onset of SE affects the severity o...

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Bibliographic Details
Main Authors: H.L. Grabenstatter, Y. Cruz Del Angel, J. Carlsen, M.F. Wempe, A.M. White, M. Cogswell, S.J. Russek, A.R. Brooks-Kayal
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002465

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http://www.sciencedirect.com/science/article/pii/S0969996113002465

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