Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid

The phospholipids, particularly phosphatidylethanolamine, of brain gray matter are enriched with docosahexaenoic acid (22:6n-3). The importance of uptake of preformed 22:6n-3 from plasma compared with synthesis from the α-linolenic acid (18:3n-3) precursor in brain is not known. Deficiency of 18:3n-...

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Bibliographic Details
Main Authors: Sheila M. Innis, Roger A. Dyer
Format: Article
Language:English
Published: Elsevier 2002-09-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328170