Critical role of tumor microenvironment in shaping NK functions: implication of hypoxic stress.

Critical role of tumor microenvironment in shaping NK functions: implication of hypoxic stress.

Blurring the boundary between innate and adaptive immune system, natural killer (NK) cells, a key component of the innate immunity, are recognized as potent anti-cancer mediators. Extensive studies have been detailed on how NK cells get activated and recognize cancer cells. In contrast, few studies...

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Bibliographic Details
Main Authors: Meriem eHasmim, Yosra eMessai, Linda eZiani, Jerome eThiery, Jean-Henri eBourhis, Muhammad Zaeem eNoman, Salem eChouaib
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Immunology
Subjects:
microenvironment
HIF
immune suppression
natural killer (NK) cells
solid tumors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00482/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00482/full

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