Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons

Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons

Genetic variants of the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene, which encodes excitatory postsynaptic core scaffolds cause numerous brain disorders. Several lines of Shank3 knock-out (KO) mice with deletions of different Shank3 exons have previously been generated and characterized....

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Bibliographic Details
Main Authors: Chunmei Jin, Hyae Rim Kang, Hyojin Kang, Yinhua Zhang, Yeunkum Lee, Yoonhee Kim, Kihoon Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Shank3
knock-out mice
transcripts
compensation
exon
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00228/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00228/full

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