Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue’s Competence for Cold-Induced Thermogenic Recruitment

Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue’s Competence for Cold-Induced Thermogenic Recruitment

Brown adipose tissue from mice living under conditions approaching human thermal and nutritional conditions (prolonged exposure to thermoneutral temperature and to an energy-rich (high-fat, high-sugar) diet) — referred to as “physiologically humanized” mice, displays morphological and molecular char...

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Bibliographic Details
Main Authors: Alexander W. Fischer, Jasper M. A. de Jong, Frederike Sass, Christian Schlein, Joerg Heeren, Natasa Petrovic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Endocrinology
Subjects:
brown fat
thermogenic capacity
UCP1
macrophages
thermoneutrality
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.568682/full

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https://www.frontiersin.org/articles/10.3389/fendo.2020.568682/full

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