Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury

Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury

The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a dynamic pluripotent modulator regulating cellular pathophysiological processes. Multiple pharmacological studies have confirmed the bene...

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Bibliographic Details
Main Authors: Mingming Shi, Fanglian Chen, Zhijuan Chen, Weidong Yang, Shuyuan Yue, Jianning Zhang, Xin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
sigma-1 receptor
calcium homeostasis
endoplasmic reticulum stress
excitotoxicity
apoptosis
inflammatory responses
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.685201/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.685201/full

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