The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study

The Oxford study of Calcium channel Antagonism, Cognition, Mood instability and Sleep (OxCaMS): study protocol for a randomised controlled, experimental medicine study

Abstract Background The discovery that voltage-gated calcium channel genes such as CACNA1C are part of the aetiology of psychiatric disorders has rekindled interest in the therapeutic potential of L-type calcium channel (LTCC) antagonists. These drugs, licensed to treat hypertension and angina, have...

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Bibliographic Details
Main Authors: Lauren Z. Atkinson, Lucy Colbourne, Alexander Smith, Catherine H. Harmer, Anna C. Nobre, Jennifer Rendell, Helen Jones, Christopher Hinds, Arne Mould, Elizabeth M. Tunbridge, Andrea Cipriani, John R. Geddes, Kate E. A. Saunders, Paul J. Harrison
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Trials
Subjects:
Bipolar disorder
Calcium blockers
Calcium channel antagonists
Depression
Functional magnetic resonance imaging
Magnetoencephalography
Online Access:http://link.springer.com/article/10.1186/s13063-019-3175-0

Internet

http://link.springer.com/article/10.1186/s13063-019-3175-0

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