Ameliorating the Metabolic Burden of the Co-expression of Secreted Fungal Cellulases in a High Lipid-Accumulating Yarrowia lipolytica Strain by Medium C/N Ratio and a Chemical Chaperone

Ameliorating the Metabolic Burden of the Co-expression of Secreted Fungal Cellulases in a High Lipid-Accumulating Yarrowia lipolytica Strain by Medium C/N Ratio and a Chemical Chaperone

Yarrowia lipolytica, known to accumulate lipids intracellularly, lacks the cellulolytic enzymes needed to break down solid biomass directly. This study aimed to evaluate the potential metabolic burden of expressing core cellulolytic enzymes in an engineered high lipid-accumulating strain of Y. lipol...

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Bibliographic Details
Main Authors: Hui Wei, Wei Wang, Hal S. Alper, Qi Xu, Eric P. Knoshaug, Stefanie Van Wychen, Chien-Yuan Lin, Yonghua Luo, Stephen R. Decker, Michael E. Himmel, Min Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Microbiology
Subjects:
fungal cellulolytic enzymes
Yarrowia lipolytica
cellulosic biofuel
cellobiohydrolase I
endoglucanase II
lipid metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03276/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.03276/full

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