CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR

The C-promoter binding factor-1 (CBF-1) is a potent and specific inhibitor of the human immunodeficiency virus (HIV)-1 LTR promoter. Here, we demonstrate that the knockdown of endogenous CBF-1 in latently infected primary CD4+ T cells, using specific small hairpin RNAs (shRNA), resulted in the react...

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Bibliographic Details
Main Authors: Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Shilpa Sonti, Sonia Zicari, Lin Sun, Aseel Alqatawni, Michael Bukrinsky, Gary Simon, Ashok Chauhan, Rene Daniel, Mudit Tyagi
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
HIV-1
latency
epigenetics
CBF-1
PRC1
PRC2
Online Access:https://www.mdpi.com/1999-4915/12/9/1040

Internet

https://www.mdpi.com/1999-4915/12/9/1040

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