Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels

Mammalian two-pore-channels (TPC1, 2; TPCN1, TPCN2) are ubiquitously- expressed, PI(3,5)P2-activated, Na+-selective channels in the endosomes and lysosomes that regulate luminal pH homeostasis, membrane trafficking, and Ebola viral infection. Whereas the channel activity of TPC1 is strongly dependen...

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Bibliographic Details
Main Authors: Xiaoli Zhang, Wei Chen, Ping Li, Raul Calvo, Noel Southall, Xin Hu, Melanie Bryant-Genevier, Xinghua Feng, Qi Geng, Chenlang Gao, Meimei Yang, Kaiyuan Tang, Marc Ferrer, Juan Jose Marugan, Haoxing Xu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
lysosomal two-pore channels
tri-cyclic antidepressants
whole-endolysosome patch clamp
lysosomal Na+ channels
Online Access:https://elifesciences.org/articles/51423

Internet

https://elifesciences.org/articles/51423

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