Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes

Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes

Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners. Thus far, functions of IL-30 have not been fully elucidated in human cells. We demon...

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Bibliographic Details
Main Authors: Carlene Petes, Mélissa K. Mariani, Yawen Yang, Nathalie Grandvaux, Katrina Gee
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
interleukin-30
interleukin-27
inflammation
human monocytes
human CD4 T cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00256/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00256/full

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