Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

Nicotinic Acetylcholine Receptor Subtype Alpha-9 Mediates Triple-Negative Breast Cancers Based on a Spontaneous Pulmonary Metastasis Mouse Model

Triple-negative breast cancer (TNBC) subtype is associated with poor prognosis and a high risk of recurrence-related death in women. Despite the aggressiveness of TNBCs, targeted TNBC therapy is not yet available in the clinic. To overcome this challenge, we generated highly metastatic TNBC cells (L...

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Bibliographic Details
Main Authors: Li-Chi Huang, Ching-Ling Lin, Jia-Zheng Qiu, Chun-Yu Lin, Kai-Wen Hsu, Ka-Wai Tam, Jung-Yu Lee, Jinn-Moon Yang, Chia-Hwa Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
triple-negative breast cancer
cancer metastasis
gene editing
α9-nAChR
epithelial–mesenchymal transition
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00336/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00336/full

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