JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

<p>Abstract</p> <p>Background</p> <p>Nitric oxide (NO) and its oxidative reaction products have been repeatedly shown to block steroid receptor function via nitrosation of zinc finger structures in the DNA-binding domain (DBD). In consequence NO-donors could be of speci...

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Bibliographic Details
Main Authors: Laschak Martin, Spindler Klaus-Dieter, Schrader Andres J, Hessenauer Andrea, Streicher Wolfgang, Schrader Mark, Cronauer Marcus V
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/12/130

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http://www.biomedcentral.com/1471-2407/12/130

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