Comparison of 2-Hydroxyglutarate Detection With sLASER and MEGA-sLASER at 7T

Comparison of 2-Hydroxyglutarate Detection With sLASER and MEGA-sLASER at 7T

The onco-metabolite 2-hydroxyglutarate (2HG), a biomarker of IDH-mutant gliomas, can be detected with 1H MR spectroscopy (1H-MRS). Recent studies showed measurements of 2HG at 7T with substantial gain in signal to noise ratio (SNR) and spectral resolution, offering higher specificity and sensitivity...

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Bibliographic Details
Main Authors: Zahra Shams, Wybe J. M. van der Kemp, Uzay Emir, Jan Willem Dankbaar, Tom J. Snijders, Filip Y. F. de Vos, Dennis W. J. Klomp, Jannie P. Wijnen, Evita C. Wiegers
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neurology
Subjects:
2-hydroxyglutarate
ultra-high field
SV MRS
MEGA-sLASER
sLASER
J-difference editing
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.718423/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.718423/full

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