IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential.

IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential.

The possibility to modulate ex vivo human NK cell differentiation towards specific phenotypes will contribute to a better understanding of NK cell differentiation and facilitate tailored production of NK cells for immunotherapy. In this study, we show that addition of a specific low dose of IL-12 to...

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Bibliographic Details
Main Authors: Dorit Lehmann, Jan Spanholtz, Caterina Sturtzel, Marleen Tordoir, Bernhard Schlechta, Dirk Groenewegen, Erhard Hofer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3909052?pdf=render

Internet

http://europepmc.org/articles/PMC3909052?pdf=render

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