CHROMATIX: computing the functional landscape of many-body chromatin interactions in transcriptionally active loci from deconvolved single cells

CHROMATIX: computing the functional landscape of many-body chromatin interactions in transcriptionally active loci from deconvolved single cells

Abstract Chromatin interactions are important for gene regulation and cellular specialization. Emerging evidence suggests many-body spatial interactions play important roles in condensing super-enhancer regions into a cohesive transcriptional apparatus. Chromosome conformation studies using Hi-C are...

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Bibliographic Details
Main Authors: Alan Perez-Rathke, Qiu Sun, Boshen Wang, Valentina Boeva, Zhifeng Shao, Jie Liang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Genome Biology
Subjects:
Chromatin folding
Polymer modeling
Super-enhancers
Topologically associated domains
Epigenomics
Histone modifications
Online Access:https://doi.org/10.1186/s13059-019-1904-z

Internet

https://doi.org/10.1186/s13059-019-1904-z

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