The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.

The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.

The role of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established, however the regulatory mechanisms modulating this phenomenon remain unclear. Here, we demonstrate that transcription factor glioma-associated oncogene 1 (GLI1) modulates...

Full description

Bibliographic Details
Main Authors: Xin Zheng, Natalia B Rumie Vittar, Xiaohong Gai, Maite G Fernandez-Barrena, Catherine D Moser, Chunling Hu, Luciana L Almada, Angela L McCleary-Wheeler, Sherine F Elsawa, Anne M Vrabel, Abdirashid M Shire, Andrea Comba, Snorri S Thorgeirsson, Youngsoo Kim, Qingguang Liu, Martin E Fernandez-Zapico, Lewis R Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3501480?pdf=render

Internet

http://europepmc.org/articles/PMC3501480?pdf=render

Similar Items