Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity

The CAG repeat expansion that elongates the polyglutamine tract in huntingtin is the root genetic cause of Huntington’s disease (HD), a debilitating neurodegenerative disorder. This seemingly slight change to the primary amino acid sequence alters the physical structure of the mutant protein and alt...

Full description

Bibliographic Details
Main Authors: Baehyun Shin, Roy Jung, Hyejin Oh, Gwen E. Owens, Hyeongseok Lee, Seung Kwak, Ramee Lee, Susan L. Cotman, Jong-Min Lee, Marcy E. MacDonald, Ji-Joon Song, Ravi Vijayvargia, Ihn Sik Seong
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Huntington's disease
full-length huntingtin
single-stranded oligonucleotide
HEAT repeats
polycomb repressive complex 2
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253118300386

Internet

http://www.sciencedirect.com/science/article/pii/S2162253118300386

Similar Items