Fab Fragment of V<sub>H</sub>H-Based Antibody Netakimab: Crystal Structure and Modeling Interaction with Cytokine IL-17A

Fab Fragment of V<sub>H</sub>H-Based Antibody Netakimab: Crystal Structure and Modeling Interaction with Cytokine IL-17A

Interleukin 17A (IL-17A) is a proinflammatory cytokine produced by Th17 cells. Antibody BCD-085 (netakimab) against human IL-17A is one of the new inhibitors of this cytokine. In netakimab, the V<sub>H</sub> domain is replaced by the V<sub>H</sub>H domain of <i>Lama gla...

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Bibliographic Details
Main Authors: Olga Kostareva, Ilya Kolyadenko, Andrey Ulitin, Victoria Ekimova, Stanislav Evdokimov, Maria Garber, Svetlana Tishchenko, Azat Gabdulkhakov
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Crystals
Subjects:
V<sub>H</sub>H domain
Fab fragment
netakimab
crystal structure
complementarity determining regions
interleukin 17A
Online Access:https://www.mdpi.com/2073-4352/9/3/177

Internet

https://www.mdpi.com/2073-4352/9/3/177

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