Gene Silencing Mediated by siRNA-binding Fusion Proteins Is Attenuated by Double-stranded RNA-binding Domain Structure

Gene Silencing Mediated by siRNA-binding Fusion Proteins Is Attenuated by Double-stranded RNA-binding Domain Structure

Delivery of small interfering RNA (siRNA) targeted to specific cell types is a significant challenge for the development of RNA interference-based therapeutics. Recently, PTD-DRBD, a double-stranded RNA binding domain (DRBD) fused to the TAT protein transduction domain (PTD), was shown to be effecti...

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Bibliographic Details
Main Authors: James C Geoghegan, Brian L Gilmore, Beverly L Davidson
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DRBD
protein transduction domain
RNA interference
siRNA delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301093

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301093

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