Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis

Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis

Psoriasis is a complex immune-mediated inflammatory skin disease characterized by T-cell-driven epidermal hyperplasia. It occurs on a strong genetic predisposition. The human leukocyte antigen (HLA)-class I allele HLA-C*06:02 on psoriasis susceptibility locus 1 (PSORS1 on 6p21.3) is the main psorias...

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Bibliographic Details
Main Author: Jörg Christoph Prinz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
psoriasis
pathogenesis
autoreactive T cells
human leukocyte antigen association
HLA-C*06:02
T-cell receptor
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00954/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00954/full

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