A Novel Oncogenic Driver in a Lung Adenocarcinoma Patient Harboring an EGFR-KDD and Response to Afatinib

A Novel Oncogenic Driver in a Lung Adenocarcinoma Patient Harboring an EGFR-KDD and Response to Afatinib

Introduction: Oncogenic mutations in the epidermal growth factor receptor (EGFR) occur frequently in patients with lung cancer. These mutations may serve as critical predictive biomarkers in patients with non-small cell lung cancer (NSCLC). Among them, EGFR exon 18–25 kinase domain duplication (EGFR...

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Bibliographic Details
Main Authors: Dong Chen, Xing-liang Li, Biao Wu, Xiao-bin Zheng, Wen-xian Wang, Hua-fei Chen, Yi-yu Dong, Chun-wei Xu, Mei-yu Fang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
epidermal growth factor receptor
kinase domain
next-generation sequencing
afatinib
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00867/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00867/full

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