Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator

Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator

Innate immune responses have been shown to influence brain development and function. Dysregulation of innate immunity is significantly associated with psychiatric disorders such as autism spectrum disorders (ASD) and schizophrenia, which are well-known neurodevelopmental disorders. Recent studies ha...

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Bibliographic Details
Main Authors: Chia-Wen eLin, Chiung-Ya eChen, Sin-Jhong eCheng, Hsiao-Tang eHu, Yi-Ping eHsueh
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Long-Term Potentiation
autism
innate immunity
Long-term depression
CDPPB
Metabotrophic glutamate receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00087/full

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