Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models

Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models

Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the cortico-striatal pathway and significantly affect the quality of life of the patients, but this has not been a therapeutic focus in HD to date. We postulated that adenosine A2A receptors (A2AR), located at...

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Bibliographic Details
Main Authors: Wei Li, Henrique B. Silva, Joana Real, Yu-Mei Wang, Daniel Rial, Ping Li, Marie-Pierce Payen, Yuanguo Zhou, Christa E. Muller, Angelo R. Tomé, Rodrigo A. Cunha, Jiang-Fan Chen
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Neurobiology of Disease
Subjects:
Adenosine A2A receptor
Huntington's disease
Cognition
Working memory
Long-term depression
R6/2 mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001278

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http://www.sciencedirect.com/science/article/pii/S0969996115001278

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