Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCδ and p38 in Human Airway Epithelial Cells

Phorbol 12-Myristate 13-Acetate Induces MUC16 Expression via PKCδ and p38 in Human Airway Epithelial Cells

ObjectivesPhorbol 12-myristate 13-acetate (PMA) is widely used as a protein kinase C (PKC) activator, PKC is involved in the secretion of mucins. MUC16, one of the membrane-bound mucins, is produced in human airway epithelial cells. However, the effect and signaling pathway of PMA on MUC16 expressio...

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Bibliographic Details
Main Authors: Chang Hoon Bae, Hak Soo Kim, Si-Youn Song, Yong-Dae Kim
Format: Article
Language:English
Published: Korean Society of Otorhinolaryngology-Head and Neck Surgery 2012-09-01
Series:Clinical and Experimental Otorhinolaryngology
Subjects:
Phorbol 12-myristate 13-acetate
Mucin
MUC16
PKCδ
p38 MAPK
Airway epithelial cell
Online Access:http://www.e-ceo.org/upload/pdf/ceo-5-161.pdf

Internet

http://www.e-ceo.org/upload/pdf/ceo-5-161.pdf

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