Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5.

Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5.

Neuroinflammatory conditions often involve dysfunction of the Blood-Brain Barrier (BBB). Therefore, identifying molecular targets that can maintain barrier fidelity is of clinical importance. We have previously reported on the anti-inflammatory effects that glycogen synthase kinase 3β (GSK3β) inhibi...

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Bibliographic Details
Main Authors: Servio H Ramirez, Shongshan Fan, Holly Dykstra, Slava Rom, Aaron Mercer, Nancy L Reichenbach, Larisa Gofman, Yuri Persidsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3572160?pdf=render

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http://europepmc.org/articles/PMC3572160?pdf=render

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