Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis

Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis

The protein kinase activity of the DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and its autophosphorylation are critical for DBS (DNA double-strand break) repair via NHEJ (non-homologous end-joining). Recent studies have shown that depletion or inactivation of DNA-PKcs kinase activity...

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Bibliographic Details
Main Authors: Pauline Douglas, Ruiqiong Ye, Laura Trinkle‑Mulcahy, Jessica A. Neal, Veerle De Wever, Nick A. Morrice, Katheryn Meek, Susan P. Lees‑Miller
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-06-01
Series:Bioscience Reports
Subjects:
DNA-dependent protein kinase
midbody
mitosis
polo-like protein kinase 1
protein phosphatase 6
Online Access:http://www.bioscirep.org/bsr/034/e113/bsr034e113.htm

Internet

http://www.bioscirep.org/bsr/034/e113/bsr034e113.htm

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