Novel Hydrogen Sulfide (H<sub>2</sub>S)-Releasing BW-HS-101 and Its Non-H<sub>2</sub>S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier

Novel Hydrogen Sulfide (H<sub>2</sub>S)-Releasing BW-HS-101 and Its Non-H<sub>2</sub>S Releasing Derivative in Modulation of Microscopic and Molecular Parameters of Gastric Mucosal Barrier

Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced molecule with anti-inflammatory and cytoprotective properties. We aimed to investigate for the first time if a novel, esterase-sensitive H<sub>2</sub>S-prodrug, BW-HS-101 with the ability to release H<sub>2&l...

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Bibliographic Details
Main Authors: Dominik Bakalarz, Edyta Korbut, Zhengnan Yuan, Bingchen Yu, Dagmara Wójcik, Aleksandra Danielak, Katarzyna Magierowska, Slawomir Kwiecień, Tomasz Brzozowski, Monika Marcinkowska, Binghe Wang, Marcin Magierowski
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
hydrogen sulfide prodrugs
BW-HS-101
non-steroidal anti-inflammatory drugs
gastrotoxicity
molecular gastroenterology
gastrointestinal pharmacology
Online Access:https://www.mdpi.com/1422-0067/22/10/5211

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https://www.mdpi.com/1422-0067/22/10/5211

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