Identification of Cancer Dysfunctional Subpathways by Integrating DNA Methylation, Copy Number Variation, and Gene-Expression Data

Identification of Cancer Dysfunctional Subpathways by Integrating DNA Methylation, Copy Number Variation, and Gene-Expression Data

A subpathway is defined as the local region of a biological pathway with specific biological functions. With the generation of large-scale sequencing data, there are more opportunities to study the molecular mechanisms of cancer development. It is necessary to investigate the potential impact of DNA...

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Bibliographic Details
Main Authors: Siyao Liu, Baotong Zheng, Yuqi Sheng, Qingfei Kong, Ying Jiang, Yang Yang, Xudong Han, Liang Cheng, Yunpeng Zhang, Junwei Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
multi-omics data
copy number variation
DNA methylation
subpathway activity
pathway topological information
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00441/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00441/full

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