Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages

Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages

Epigenetic modifications regulate gene expression in the host response to a diverse range of pathogens. The extent and consequences of epigenetic modification during macrophage responses to Streptococcus pneumoniae, and the role of pneumolysin, a key Streptococcus pneumoniae virulence factor, in inf...

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Bibliographic Details
Main Authors: Joby Cole, Adrienn Angyal, Richard D. Emes, Tim John Mitchell, Mark J. Dickman, David H. Dockrell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
histone post translational modifications
Streptococcus pneumoniae
pneumolysin
tumour necrosis factor
monocyte derived macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.573266/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.573266/full

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