Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient

Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient

This mini-review provides the entire experimental history of the development of the old neuroleptic thioridazine (TZ) for therapy of antibiotic resistant pulmonary tuberculosis infections. TZ is effective when used in combination with antibiotics to which the initial Mycobacterium tuberculosis was r...

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Bibliographic Details
Main Authors: Joseph Molnar, Leonard Amaral
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Pharmaceuticals
Subjects:
pulmonary tuberculosis
thioridazine
in vitro activity
ex vivo activity
cures the mouse of MDR-Mtb infections
XDR-TB
TDR-TB
cures the human of an XDR-TB infection
mechanisms of action
inhibitor of efflux pumps
enhances killing of intracellular Mtb
Online Access:http://www.mdpi.com/1424-8247/5/9/1021

Internet

http://www.mdpi.com/1424-8247/5/9/1021

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