Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway

Inhibition of Prostate Cancer DU-145 Cells Proliferation by Anthopleura anjunae Oligopeptide (YVPGP) via PI3K/AKT/mTOR Signaling Pathway

We investigated the antitumor mechanism of Anthopleura anjunae oligopeptide (AAP-H, YVPGP) in prostate cancer DU-145 cells in vitro and in vivo. Results indicated that AAP-H was nontoxic and exhibited antitumor activities. Cell cycle analysis indicated that AAP-H may arrest DU-145 cells in the S pha...

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Bibliographic Details
Main Authors: Xiaojuan Li, Yunping Tang, Fangmiao Yu, Yu Sun, Fangfang Huang, Yan Chen, Zuisu Yang, Guofang Ding
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Marine Drugs
Subjects:
prostate cancer
Anthopleura anjunae oligopeptide
DU-145 cells
PI3K/AKT/mTOR signaling pathway
Online Access:http://www.mdpi.com/1660-3397/16/9/325

Internet

http://www.mdpi.com/1660-3397/16/9/325

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