The Impact of CXCR4 Blockade on the Survival of Rat Brain Cortical Neurons

The Impact of CXCR4 Blockade on the Survival of Rat Brain Cortical Neurons

Background: Chemokine receptor type 4 (CXCR4) plays a role in neuronal survival/cell repair and also contributes to the progression of cancer and neurodegenerative diseases. Chemokine ligand 12 (CXCL12) binds to CXCR4. In this study, we have investigated whether CXCR4 blockade by AMD3100 (a CXCR4 an...

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Bibliographic Details
Main Authors: José Joaquín Merino, Alba Garcimartín, María Elvira López-Oliva, Juana Benedí, María Pilar González
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
AMD3100
CXCR4 chemokine receptor
cortical neurons in vitro
caspase-3/9
apoptosis
cytochrome c/Bcl-2/Bax
mitochondria
cytosol
neuroprotection
Online Access:http://www.mdpi.com/1422-0067/17/12/2005

Internet

http://www.mdpi.com/1422-0067/17/12/2005

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