Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges

Extracellular ATP activates inflammasome and triggers the release of multiple cytokines in various immune cells, a process primarily mediated by P2X7 receptors. However, the expression and functional properties of P2X7 receptors in native mast cells in tissues such as meninges where migraine pain or...

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Bibliographic Details
Main Authors: Dilyara Nurkhametova, Igor Kudryavtsev, Valeriia Guselnikova, Maria Serebryakova, Raisa R. Giniatullina, Sara Wojciechowski, Fatma Tore, Albert Rizvanov, Jari Koistinaho, Tarja Malm, Rashid Giniatullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
mast cells
ATP
P2X7 receptor
degranulation
neuroinflammation
migraine
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00045/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00045/full

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