High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods

High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods

Abstract Background Next generation sequencing (NGS) is being increasingly applied for assisting cancer molecular diagnosis. However, it is still needed to validate NGS accuracy on detection of DNA alternations based on a large number of clinical samples, especially for DNA rearrangements and copy n...

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Bibliographic Details
Main Authors: Dan Su, Dadong Zhang, Kaiyan Chen, Jing Lu, Junzhou Wu, Xinkai Cao, Lisha Ying, Qihuang Jin, Yizhou Ye, Zhenghua Xie, Lei Xiong, Weimin Mao, Fugen Li
Format: Article
Language:English
Published: BMC 2017-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Targeted next generation sequencing
Amplification-refractory mutation system
Fluorescence in situ hybridization
Immunohistochemistry
Clinical tumor samples
Online Access:http://link.springer.com/article/10.1186/s13046-017-0591-4

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http://link.springer.com/article/10.1186/s13046-017-0591-4

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