Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity

Proposition of a novel animal model of systemic sclerosis induced by type V collagen in C57BL/6 mice that reproduces fibrosis, vasculopathy and autoimmunity

Abstract Background Type V collagen (Col V) has the potential to become an autoantigen and has been associated with the pathogenesis of systemic sclerosis (SSc). We characterized serological, functional, and histopathological features of the skin and lung in a novel SSc murine model induced by Col V...

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Bibliographic Details
Main Authors: Walcy Rosolia Teodoro, Zelita Aparecida de Jesus Queiroz, Lais Araujo dos Santos, Sergio Catanozi, Antonio dos Santos Filho, Cleonice Bueno, Margarete B. G. Vendramini, Sandra de Morais Fernezlian, Esmeralda M. Eher, Percival D. Sampaio-Barros, Sandra Gofinet Pasoto, Fernanda Degobbi T. Q. S. Lopes, Ana Paula Pereira Velosa, Vera Luiza Capelozzi
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Arthritis Research & Therapy
Subjects:
Type V collagen
Systemic sclerosis
Mouse model
Vascular
Fibrosis
Autoantibodies
Online Access:https://doi.org/10.1186/s13075-019-2052-2

Internet

https://doi.org/10.1186/s13075-019-2052-2

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