In vivo continuous evolution of metabolic pathways for chemical production

In vivo continuous evolution of metabolic pathways for chemical production

Abstract Microorganisms have long been used as chemical plant to convert simple substrates into complex molecules. Various metabolic pathways have been optimised over the past few decades, but the progresses were limited due to our finite knowledge on metabolism. Evolution is a knowledge-free geneti...

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Bibliographic Details
Main Authors: Zheng Lin Tan, Xiang Zheng, Yinan Wu, Xingjin Jian, Xinhui Xing, Chong Zhang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Microbial Cell Factories
Subjects:
In vivo continuous evolution
In vivo genotype diversification
Fitness-coupled selection pressure
Equipment maintaining continuous culture
Metabolic pathway evolution
Chemical bioproduction
Online Access:http://link.springer.com/article/10.1186/s12934-019-1132-y

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http://link.springer.com/article/10.1186/s12934-019-1132-y

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