Identification of Genetic Modifiers of CagA-Induced Epithelial Disruption in Drosophila

Identification of Genetic Modifiers of CagA-Induced Epithelial Disruption in Drosophila

Helicobacter pylori strains containing the CagA protein are associated with high risk of gastric diseases including atrophic gastritis, peptic ulcers, and gastric cancer. CagA is injected into host cells via a Type IV secretion system where it activates growth factor-like signaling, disrupts cell-ce...

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Bibliographic Details
Main Authors: David W. Reid, Jonathan B. Muyskens, James T. Neal, Gino W. Gaddini, Lucy Y. Cho, Anica M. Wandler, Crystal M. Botham, Karen eGuillemin
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Drosophila
Eye
Helicobacter pylori
Epithelia
CagA
coracle
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00024/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00024/full

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