Combined Treatment with Exendin-4 and Metformin Attenuates Prostate Cancer Growth.

Recently, the pleiotropic benefits of incretin-based therapy have been reported. We have previously reported that Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist, attenuates prostate cancer growth. Metformin is known for its anti-cancer effect. Here, we examined the anti-cancer effect...

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Bibliographic Details
Main Authors: Yoko Tsutsumi, Takashi Nomiyama, Takako Kawanami, Yuriko Hamaguchi, Yuichi Terawaki, Tomoko Tanaka, Kunitaka Murase, Ryoko Motonaga, Makito Tanabe, Toshihiko Yanase
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4595004?pdf=render