Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

Saturated Fatty Acid Activates T Cell Inflammation Through a Nicotinamide Nucleotide Transhydrogenase (NNT)-Dependent Mechanism

Circulating fatty acids (FAs) increase with obesity and can drive mitochondrial damage and inflammation. Nicotinamide nucleotide transhydrogenase (NNT) is a mitochondrial protein that positively regulates nicotinamide adenine dinucleotide phosphate (NADPH), a key mediator of energy transduction and...

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Bibliographic Details
Main Authors: Grace McCambridge, Madhur Agrawal, Alanna Keady, Philip A. Kern, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Biomolecules
Subjects:
mitochondria
nicotinamide nucleotide transhydrogenase
oleate
palmitate
peripheral blood mononuclear cells, reactive oxygen species, Th17 cytokines
Online Access:https://www.mdpi.com/2218-273X/9/2/79

Internet

https://www.mdpi.com/2218-273X/9/2/79

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