Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone

Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone

Impairment of mucociliary clearance with reduced airway fluid secretion leads to chronically inflamed airways. Cystic fibrosis transmembrane conductance regulator (CFTR) is crucially involved in airway fluid secretion and dexamethasone (dexa) has previously been shown to elevate CFTR activity in air...

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Bibliographic Details
Main Authors: Miriam Bossmann, Benjamin W. Ackermann, Ulrich H. Thome, Mandy Laube
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
cystic fibrosis transmembrane conductance regulator
glucocorticoids
dexamethasone
airway
phosphoinositide 3-kinase
serum and glucocorticoid dependent kinase 1
protein kinase B
neural precursor cell expressed, developmentally downregulated 4-like
Online Access:https://www.mdpi.com/1422-0067/18/8/1807

Internet

https://www.mdpi.com/1422-0067/18/8/1807

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