A core-shell structured COVID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity

Abstract Although inoculation of COVID-19 vaccines has rolled out globally, there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries. Here, we report on the development of a highly efficacious mRNA vaccine, SW0123 that is composed of sequen...

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Bibliographic Details
Main Authors: Ren Yang, Yao Deng, Baoying Huang, Lei Huang, Ang Lin, Yuhua Li, Wenling Wang, Jingjing Liu, Shuaiyao Lu, Zhenzhen Zhan, Yufei Wang, Ruhan A, Wen Wang, Peihua Niu, Li Zhao, Shiqiang Li, Xiaopin Ma, Luyao Zhang, Yujian Zhang, Weiguo Yao, Xingjie Liang, Jincun Zhao, Zhongmin Liu, Xiaozhong Peng, Hangwen Li, Wenjie Tan
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00634-z