Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities.

Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to vaccine design. However, current methods depend on indirect measures or on ex vivo expanded CTL clones. We her...

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Bibliographic Details
Main Authors: Ellen M Leitman, Christine D Palmer, Søren Buus, Fabian Chen, Lynn Riddell, Stuart Sims, Paul Klenerman, Asier Sáez-Cirión, Bruce D Walker, Paul R Hess, Marcus Altfeld, Philippa C Matthews, Philip J R Goulder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5636067?pdf=render

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http://europepmc.org/articles/PMC5636067?pdf=render

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