Anti-Toxoplasma gondii activity of 5-oxo-hexahydroquinoline derivatives: synthesis, in vitro and in vivo evaluations, and molecular docking analysis

Anti-Toxoplasma gondii activity of 5-oxo-hexahydroquinoline derivatives: synthesis, in vitro and in vivo evaluations, and molecular docking analysis

Background and purpose: The aim of this study was to evaluate the in vitro and in vivo anti-Toxoplasma gondii (T. gondii) effect of 5-oxo-hexahydroquinoline compounds. Moreover, molecular docking study of the compounds into the active site of enoyl-acyl carrier protein reductase (ENR) as a necessary...

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Bibliographic Details
Main Authors: Mohammadsaeid Zahedi, Qasem Asgari, Fatemeh Badakhshan, Amirhossein Sakhteman, Sara Ranjbar, Mehdi Khoshneviszadeh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
flow cytometry; molecular docking; 5-oxo-hexahydroquinoline; propidium iodide; toxoplasma
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=4;spage=367;epage=380;aulast=Zahedi

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2020;volume=15;issue=4;spage=367;epage=380;aulast=Zahedi

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