Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

Summary: The Tousled-like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaperone and influence cell cycle progression and genome maintenance, yet the mechanisms underlying TLK-mediated genome stability remain uncertain. Here, we show that TLK loss results in severe ch...

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Bibliographic Details
Main Authors: Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, Lars M. Koenig, Maria Sanchiz-Calvo, Simon J. Boulton, Travis H. Stracker
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
TLK1
TLK2
ASF1
heterochromatin
H3.3
telomeres
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720309682

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720309682

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